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Medicine that inhibit CYP2D6 activity, like paroxetine and quinidine, may result in decreased clearance of oxycodone which could lead on to a rise in oxycodone plasma concentrations. Concurrent administration of quinidine resulted in a rise in oxycodone Cmax by eleven%, AUC by thirteen%, and t½ elim.Ritonavir or lopinavir/ritonavir tremendously im